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. 2012 Sep 27;4:4. doi: 10.3389/fnsyn.2012.00004

Figure 3.

Figure 3

H1a expression alters the maintenance of CA3-CA1 LTP in pyramidal CA1 neurons. In comparison to the normalized amplitudes of the EPSCs of WT mice (A), the amplitudes of EPSCs recorded from H1a TG mice (B), after the initial potentiation, declined to the baseline levels within 20 min in the two-pathway LTP experiment, using the “pairing” protocol for induction. The analysis of LTP experiments obtained from Homer1 KO mice (C) revealed no differences when compared to WT, using “pairing” as an induction protocol. Closed circles: potentiated pathway; open circles: control pathway. Panel (D) represents an overlay of the potentiated pathways from WT (closed circles), Homer1 KO (open circles) and H1a TG (open squares) mice, using “pairing” as LTP induction protocol. Error bars are SEM.