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. 2012 Sep 27;4:4. doi: 10.3389/fnsyn.2012.00004

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Copyright © 2012 Rozov, Zivkovic and Schwarz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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LTP profiles recorded from CA1 pyramidal neurons infected with a lentivirus expressing H1a-Venus. (A) Two-pathway LTP induced by the “pairing” protocol in CA3-CA1 synapses of WT mice stereotaxically injected with a lentivirus expressing H1a-Venus (H1aV) resulted in a transient potentiation of synaptic responses recorded from infected pyramidal neurons (open circles) of mutated H1aV (W234A) after lentivirus injection in WT mice showed an unaltered LTP profile of the paired pathway (closed circles). (B) Cellular LTP induced by the “pairing” protocol in either Homer1 KO (closed circles), or GluA2 KO (open circles) mice stereotaxically injected with lentivirus expressing H1aV revealed a comparable, stable potentiation of the paired pathway when recorded from infected, fluorescent cells. Error bars are SEM.