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. Author manuscript; available in PMC: 2013 Oct 5.
Published in final edited form as: Org Lett. 2012 Sep 17;14(19):5086–5089. doi: 10.1021/ol3023374

Figure 1.

Figure 1

(A) Classical GT reaction in which glycoside formation is thermodynamically favored. (B) GT reaction where an appropriately ‘activated’ glycoside donor (Donor*) shifts the reaction thermodynamics to favor sugar nucleotide formation. (C) One-pot coupled dual-GT-catalyzed reaction which combines GT-driven (OleD) sugar nucleotide synthesis with a subsequent GT-catalyzed (GtfE) glycosylation reaction to ultimately accomplish transglycosylation from a synthetic aromatic glycoside to a targeted aglycon (in this case, the vancomycin aglycon 3).