Table 7.

 Frequency and duration of night time awakenings and wake up time in study of effect of melatonin on sleep problems in children with neurodevelopmental disorders

	Melatonin (n=51)				Placebo (n=59)			Adjusted difference (95% CI)
	Baseline	Week 12	Change		Baseline	Week 12	Change
No of wakes	0.9 (1.3)	0.8 (1.2)	−0.1 (−0.4 to 0.1)		0.7 (1.6)	0.6 (1.5)	−0.1 (−0.3 to 0.1)	0.0 (−0.3 to 0.3)
Total duration of nightly wakes (min)	24.5 (32.7)	16.8 (26.3)	−7.7 (−15.5 to 0.2)		11.0 (17.4)	9.7 (22.3)	−1.3 (−8.6 to 6.0)	2.8 (−6.2 to 11.7)
Wake up time (min from midnight)	443.1 (59.1)	426.4 (66.2)	−16.7 (−103.3 to 70.0)		453.9 (54.6)	464.8 (57.3)	10.9 (−77.1 to 98.9)	−29.9 (−46.3 to −13.6)*

*P<0.001.