Table 2.
Distribution of GO processes in glaucomatous optic nerve astrocytes revealed by proteomics
| Top 10 GO processes (for 35 proteins) |
p-value | Top 10 canonical maps (for 20 mapped proteins) |
p-value |
|---|---|---|---|
| Complement activation. Alternative pathway | 3.60E-06 | CDC42 in cellular processes | 1.10E-03 |
| Response to heat | 1.10E-05 | Alternative complement pathway | 1.70E-03 |
| Nucleosome assembly | 3.80E-05 | Putative ubiquitin pathway | 3.10E-03 |
| Complement activations | 4.10E-05 | Role of ASK1 under oxidative stress | 3.20E-03 |
| Glycogen catabolism | 5.40E-05 | Role of IAP proteins in apoptosis | 4.10E-03 |
| DNA DSB repair via homologous recombination | 1.00E-04 | Glucocorticoid receptor signaling | 5.10E-03 |
| Chromosome organization | 1.40E-04 | Role of Akt in hypoxia | 7.80E-03 |
| Carbohydrate metabolism | 1.50E-04 | Parkin disorder under Parkinson's disease | 8.10E-03 |
| Innate immune response | 2.20E-04 | Role of Parkin in the ubiquitin-proteosomal family | 8.10E-03 |
| Small GTPase mediated signal transduction | 3.10E-04 | Urea cycle | 3.40E-02 |