Table 2.
Follicular Lymphoma International Prognostic Index (FLIPI) and Follicular Lymphoma International Prognostic Index 2 (FLIPI 2)
| FLIPI | ||||
|---|---|---|---|---|
|
Risk factors | ||||
| · Age <60 years vs. ≥60 years |
|
|
|
|
| · Hemoglobin ≥12 g/dL vs. <12 g/dL |
|
|
|
|
| · Serum LDH ≤ ULN vs. >ULN* |
|
|
|
|
| · Ann Arbor stage I-II vs. III-IV |
|
|
|
|
| · No. of nodal sites ≤4 vs. >4 |
|
|
|
|
|
Risk group |
No. of factors |
5–year OS** |
10–year OS** |
Relative risk |
| Good |
0–1 |
91% |
71% |
1 |
| Intermediate |
2 |
78% |
51% |
2.3 |
| Poor |
≥3 |
53% |
36% |
4.3 |
|
FLIPI 2 | ||||
|
Risk factors | ||||
| · Beta-2-microglobulin > ULN* |
||||
| · Longest diameter of the largest involved node > 6 cm |
|
|
|
|
| · Bone marrow involvement |
|
|
|
|
| · Hemoglobin level < 12 gr/L |
|
|
|
|
| · Age older than 60 years |
|
|
|
|
|
Risk group |
No. of factors |
3-year PFS*** |
5-year PFS*** |
Relative risk |
| Low |
0 |
90.9% |
79.5% |
1 |
| Intermediate |
1-2 |
69.3% |
51.2% |
3.19 |
| High | 3-5 | 51.3% | 18.8% | 5.76 |
* ULN: under limits normal.
** OS: overall survival.
*** PFS: progression free survival.