Table 3.
Univariable relative risk ratios and odds ratios for each of having one or two ears affected by congenital hereditary sensorineural deafness (CHSD) rather than no ears affected in Australian Cattle Dogs from multinomial logistic models and cumulative proportion animal models
|
Variable |
Multinomial logistic model* |
Multinomial cumulative proportion animal model** |
||||
|---|---|---|---|---|---|---|
| |
One ear affected |
Two ears affected |
Odds ratio (95% CI)† | P-value*** | ||
| Relative risk ratio (95% CI)† | P-value*** | Relative risk ratio (95% CI)† | P-value*** | |||
|
Sex |
|
|
|
0.155 |
|
0.069 |
| Male |
Reference category |
|
Reference category |
|
Reference category |
|
| Female |
1.7 (1.0 to 2.8) |
0.056 |
1.4 (0.6 to 3.0) |
0.447 |
1.6 (1.0 to 2.5) |
0.067 |
|
Colour |
|
|
|
0.913 |
|
0.940 |
| Red |
Reference category |
|
Reference category |
|
Reference category |
|
| Blue |
0.9 (0.4 to 2.1) |
0.857 |
1.5 (0.6 to 4.2) |
0.402 |
1.1 (0.5 to 2.2) |
0.878 |
| Blue black tan |
0.9 (0.5 to 1.8) |
0.862 |
1.1 (0.4 to 3.1) |
0.828 |
0.9 (0.5 to 1.7) |
0.784 |
| Blue tan |
**** |
|
|
|
0.7 (0.1 to 3.1)***** |
0.605 |
| Red tan |
|
|
|
|
|
|
| Blue black |
|
|
|
|
|
|
| Blue mottled |
|
|
|
|
|
|
| Red mottled |
|
|
|
|
|
|
|
Base colour |
|
|
|
0.886 |
|
0.876 |
| Blue |
Reference category |
|
Reference category |
|
Reference category |
|
| Red |
1.1 (0.6 to 1.8) |
0.853 |
0.8 (0.4 to 2.0) |
0.704 |
1.0 (0.6 to 1.8) |
0.876 |
| Blue black tan |
|
|
|
0.992 |
|
0.783 |
| No |
Reference category |
|
Reference category |
|
Reference category |
|
| Yes |
1.0 (0.5 to 1.8) |
0.922 |
1 (0.4 to 2.5) |
0.958 |
0.9 (0.5 to 1.6) |
0.789 |
|
Speckled |
|
|
|
0.834 |
|
0.727 |
| No |
Reference category |
|
Reference category |
|
Reference category |
|
| Yes |
1.1 (0.6 to 1.9) |
0.756 |
0.8 (0.4 to 2.0) |
0.681 |
1.1 (0.7 to 1.8) |
0.733 |
|
Mask |
|
|
|
<0.001 |
|
0.002 |
| No |
Reference category |
|
Reference category |
|
Reference category |
|
| Left |
0.9 (0.4 to 2.1) |
0.760 |
2.9 (0.8 to 10.1) |
0.099 |
0.9 (0.4 to 2.2) |
0.902 |
| Right |
1.0 (0.4 to 2.6) |
0.962 |
3.4 (0.7 to 17.0) |
0.142 |
1.2 (0.5 to 2.7) |
0.712 |
| Bilateral |
0.2 (0.1 to 0.5) |
0.001 |
0.5 (0.1 to 2.5) |
0.425 |
0.2 (0.1 to 0.5) |
0.001 |
|
Pigmented body spot |
|
|
|
0.056 |
|
0.046 |
| None |
Reference category |
|
Reference category |
|
Reference category |
|
| At least one |
0.4 (0.1 to 1.0) |
0.052 |
0.3 (0.0 to 1.8) |
0.176 |
0.4 (0.1 to 1.0) |
0.044 |
|
White head/body patches |
|
|
|
0.952 |
|
0.899 |
| No |
Reference category |
|
Reference category |
|
Reference category |
|
| Yes |
0.9 (0.2 to 4.3) |
0.892 |
1.3 (0.2 to 11.2) |
0.784 |
0.9 (0.2 to 3.4) |
0.905 |
|
Sire CHSD status |
|
|
|
<0.001 |
|
0.209 |
| Normal tested by first-named author |
Reference category |
|
Reference category |
|
Reference category |
|
| Unilateral left | 4.1 (1.5 to 11.1) | 0.006 | 6.0 (1.7 to 20.9) | 0.005 | 3.2 (0.5 to 19.1) | 0.203 |
*Standard errors adjusted for clustering by litter.
** Multinomial cumulative proportion animal ‘threshold’ models using the full pedigree (ie all pedigree data that were available), with dog fitted as a random effect.
*** Bolded P-values are overall Wald P-values; unbolded P-values are Wald P-values for each coefficient.
**** Last 5 categories excluded from analysis as none of these dogs had both ears affected.
***** Last 5 categories were pooled for analyses.
† 95% CI indicates 95% confidence interval.