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. 2012 Nov 5;7(11):e48388. doi: 10.1371/journal.pone.0048388

Table 1. Diabetic and control rat corneas: clinical data and observations by SHG microscopy and other imaging techniques.

Sex Animal Blood glucose level (mg/mL) Age (months) Cornea Presence of collagen(SHG microscopy) Other imaging techniques
center periphery
Goto-Kakizaki rats
M 1 507 12 1a right +++ CM
1b left +++ CM, histology, TEM
2 559 14 2a left +++
F 3 231 12 3a right +++ CM
3b left +++ CM
4 220 12 4a left + +++ CM, histology, TEM
5 422 14 5b right +++ Histology, TEM
Wistar rats
M 6 N/A 5 6a left CM
7 N/A 14 7a left + + CM, histology
8 N/A 5 8a right CM
N/A 8b left CM

Grading is as follows: N/A: not available, −: absence of fibrillar collagen, +: few fibrillar collagen, ++: great concentration of fibrillar collagen, +++: fibrillar collagen over the whole field of view.