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. 2012 Jun 25;13(1):55. doi: 10.1186/1465-9921-13-55

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Copyright ©2012 Iwashita et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CLCA1 protein expression in airway epithelium. Immunohistochemical staining for CLCA1 in lung sections from (A) a non-smoker, (B) a smoker without COPD, and (C) a COPD patient. (A-C) Scale bars = 100 μm. CLCA1 protein was strongly expressed in the airway epithelia (bronchioles and terminal bronchioles) and minimally expressed in smooth muscles of the smoker and COPD patient. (D-F) Magnified images of panel A (D), panel B (E), and panel C (F). (G-I) Control experiments using rabbit IgG for the same lung sections from (G) a non-smoker, (H) a smoker without COPD, and (I) a COPD patient (D-I: scale bars = 40 μm).