Table 4.
Evaluation of involvement of serotonergic, nitrergic, KATPchannels, and TRPV1 receptors in the antinociceptive effect of BISA in MO test
| Group | Dose (mg/kg) | Specific behaviors |
|---|---|---|
| Normal |
- |
88.25 ± 18.59** |
| Vehicle |
- |
181.90 ± 24.07 |
| BISA |
50 |
115.70 ± 25.33* |
| BISA + Ondansetron |
50 + 0.5 |
57.13 ± 11.07*** |
| BISA + L-NAME |
50 + 20 |
31.25 ± 8.64*** |
| BISA + glibenclamide |
50 + 5 |
86.57 ± 15.61* |
| BISA + ruthenium red | 50 + 3 | 61.71 ± 8.41** |
Values represent the mean ± SEM of pain-related behaviors (licking of abdomen, stretching, abdominal retractions). *p < 0.05, **p < 0.01 and ***p < 0.001 versus vehicle (ANOVA, Student-Newman-Keul’s test).