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. 2012 Nov 5;7(11):e49269. doi: 10.1371/journal.pone.0049269

Figure 1. Overview of lipid metabolism in yeast and the enzymes deleted within this work.

Figure 1

Formation of lyso-PA from dihydroxyacetone phosphate (DHAP) is mediated by synthesis and reduction of 1-acyl-DHAP. Compounds in alphabetic order: Acyl-CoA, acyl-coenzymeA; CDP-DAG, cytidinediphosphate-diacylglycerol; DAG, diacylglycerol; DHAP, dihydroxyacetone phosphate; FFA, free fatty acid; Glycerol-3-P, glycerol-3-phosphate; Lyso-PA, lyso-phosphatidic acid; Lyso-PL, lyso-phospholipid; PA, phosphatidic acid; PL, phospholipid; SE, steryl ester; TAG, triacylglycerol. Enzymatic activities in alphabetic order: Are1,2, acyl-CoA:sterol acyltransferase 1 and 2; Dga1, diacylglycerol acyltransferase 1; Faa1,2,3,4 and Fat1, fatty acid activation 1 to 4 and fatty acid transporter 1 (acyl-CoA synthetases); Lro1, phospholipid:diacylglycerol acyltransferase (PDAT); Nte1, phosphatidylcholine phospholipase B; Plb1,2,3, phospholipase B 1 to 3; Tgl1,Yeh1,Yeh2, steryl ester hydrolases; Tgl2,3,4,5, triacylglycerol lipase 2 to 5.