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. 2012 Jul 23;2(5):563–575. doi: 10.1002/brb3.75

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Copyright © 2012 Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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The C57BL6 SOD1^G93A/Gal-3^−/− phenotype (n = 12) displays greater functional impairment and weight loss than the C57BL6 SOD1^G93A/Gal-3^+/+ cohort (n = 12) during disease progression. Mean ± SEM scores of C57BL6 SOD1^G93A/Gal-3^−/− or C57BL6 SOD1^G93A/Gal-3^+/+ control mice are graphed over time for individual tests of motor function or body weight. The vertical rise score reflects the number of times animals reared up onto their hind limbs to explore during 3 min in an open field chamber. Rotarod and grip strength tests are detailed in Methods. For all, *P < 0.05 by two-way ANOVA followed by individual post hoc t-tests for each time point.