Figure 1.

Amino acid sequence of α-syn and the schematic representation of mutants used in this study. (a) Amino acid sequence of α-syn. Open squares indicate the imperfect KTKEGV repeats. The closed square indicates the fibril core region determined previously. The NAC region is indicated by a dotted line under the sequence. Acidic amino acid residues are represented in bold and the tyrosine residues mutated in this study are underlined. The position of the C-terminal amino acid in the truncated mutants are denoted by arrows. (b) Schematic drawing of the relative polypeptide length and negative charge distributions of the C-terminal truncated or mutated proteins. The open boxes represent the imperfect KTKEGV region.