Table 5.
Areas showing positive correlations between scales measuring symptom severity in the ASD group and increased activity when viewing “beat gesture with speech” versus “still frame with speech”
Anatomical region | Peak (MNI; mm) | Extent (voxels) | Max (t) | Cluster (P) | ||
---|---|---|---|---|---|---|
ADOS-G Communication Subscale | ||||||
Left inferior and middle occipital gyri and posterior middle temporal gyrus | −34 | −68 | 0 | 800 | 10.03 | 0.001 |
Right posterior inferior and middle temporal gyri, inferior and middle occipital gyri and calcarine and lingual gyri | 50 | −72 | 0 | 725 | 24.92 | 0.001 |
Right hippocampus | 22 | −28 | −4 | 57 | 6.14 | 0.034 |
ADOS-G Social Subscale | ||||||
Left inferior and middle occipital gyri and posterior middle temporal gyrus | −34 | −66 | −2 | 961 | 9.86 | 0.001 |
Right posterior inferior and middle temporal gyri, inferior and middle occipital gyri and calcarine and lingual gyri | 50 | −68 | 2 | 782 | 20.21 | 0.001 |
Right hippocampus | 22 | −28 | −4 | 91 | 6.17 | 0.002 |
Social Responsiveness Scale (SRS) | ||||||
Left inferior and middle occipital gyri and posterior middle temporal gyrus | −34 | −66 | −2 | 822 | 8.07 | 0.001 |
Right posterior inferior temporal gyrus and inferior and middle occipital gyri and lingual gyrus | 50 | −72 | 0 | 701 | 23.61 | 0.001 |
Right hippocampus | 22 | −28 | −4 | 36 | 6.13 | 0.028 |
ADOS-G, Autism Diagnosis Observation Schedule-Generic (Lord et al. 2000); x, y, and z = the MNI coordinates (mm) corresponding to the left–right, anterior–posterior, and inferior–superior axes, respectively; t, the highest t-score within a region; thresholded at t > 3.36 (P < 0.005); corrected for multiple comparisons at the cluster level (P < 0.05).