Figure 7. Channel kinetics of I_to and I_Kur were analyzed in Rgs5^−/− and WT cardiomyocytes, respectively.

The steady-state inactivation (A) and reactivation (B) of curves in I_to plotted similar tendency between Rgs5^−/− and wild-type atrial myocytes. However, the property of I_Kur in Rgs5^−/− cardiomyocytes showed markedly modification with significant difference of half-inactivated voltage (V_1/2) (C) and reactivated time constant (τ) (D). Histogram summarized the statistical significance of V_1/2 and τ in WT and Rgs5^−/− groups (E, F).