Table 3. Electrophysiological parameters recorded in isolated mouse heart.
WT (n = 18) | Rgs5−/− (n = 18) | P | |
RR | 154.6±28.3 | 167.5±32.1 | NS |
AERP200 | 38.6±7.6 | 41.9±7.7 | NS |
AERP150 | 37.6±6.5 | 43.4±8.8 | <0.05 |
AERP125 | 36.5±6.6 | 44.9±8.8 | <0.01 |
AERP100 | 36.2±4.7 | 47.0±11.1 | <0.01 |
AVERP200 | 50.0±12.0 | 58.2±16.3 | NS |
AVERP150 | 53.0±11.2 | 59.0±17.3 | NS |
AVERP125 | 51.9±12.8 | 54.9±13.6 | NS |
AVERP100 | 52.6±14.2 | 46.2±6.5 | NS |
WCL | 66.8±11.9 | 87.1±20.6 | <0.01 |
SNRT | 237.5±45.5 | 312.4±67.9 | <0.01 |
cSNRT | 84.9±11.2 | 144.8±31.7 | <0.01 |
SNRTi | 1.5±0.1 | 1.8±0.4 | <0.01 |
Values are means±SE. AERP, atrial effective refractory periods; AVERP, atrioventricular effective refractory periods; WCL, Wenkebach cycle length. SNRT, sinus nodal recovery time; cSNRT, corrected sinus nodal recovery time; SNRTi, sinus nodal recovery time index. Subscripts 200, 150, 125 and 100 refer to S1 drive cycle lengths of 200, 150,125 and 100 ms, respectively. NS: no statistical significance.