Table 2.

Treatment of uncomplicated falciparum malaria in adults[79]

	Adult Patients
	Drug	Dosage	Comment
First line	Artemether/Lumefantrine (Riamet™)	Twice daily for three days >35 kg: 4 tablets each 20 mg/120 mg for 6 doses (0–8–24–36–48–60 hours)	Take with fatty food, reduced efficacy in Cambodia and border regions of Thailand
	Dihydroartemisinin/Piperaquine (Eurartesim™)°	Once daily for three days 36 <75 kg: 3 tablets each 320 mg/40 mg, 75-100 kg: 4 tablets each 320 mg/40 mg, daily for three days	Administration without food, at least 3 hours from any meal
	Atovaquone/Proguanil (Malarone™)	Once daily for 3 days >40 kg: 4 tablets each 250/100 mg	Administration with fatty food
Second line	Quinine*/Doxycycline	Thrice daily 10 mg/kg quinine plus daily 200 mg doxycycline for 7 days	Loose drug combination, off-label use
	Quinine*/Clindamycin	Thrice daily 10 mg/kg quinine plus twice daily 10 mg/kg clindamycin for 7 days	Loose drug combination, off-label use
	Mefloquine (Lariam™)	Split total dose in 2–3 doses 6–8 hours apart 45-60 kg: 5 tablets (3 + 2 tablets) >60 kg: 6 tablets (3 + 2 + 1 tablets)	Administration after food intake monotherapy, which is not suitable for regions with multidrug resistant falciparum malaria (SE-Asia)

*Quinine dose provided as quinine sulphate °Eurartesim tablet strengths are Dihydroartemisinin/piperaquine 20 mg/160 mg and Dihydroartemisinin/piperaquine 40 mg/320 mg.