Table 1. List of unspecific modifiers of polyQ-induced toxicity.
| Name/CG | Effect on Tau-induced REP | Effect on polyQ-induced REP | Predicted molecular function/biological process (as listed on flybase.org) |
| Rab30/CG9100 | E | E | GTPase activity/involved in vesicle sorting and transport |
| Aats-his/CG6335 | E | E | histidine-tRNA ligase/histidyl-tRNA aminoacylation |
| MED14/CG12031 | E | E | protein binding/transcription from RNA polymerase II promoter |
| Prp8/CG8877 | E | E | unknown/nuclear mRNA splicing, via spliceosome |
| Nelf-E/CG5994 | E | E | mRNA binding/negative regulation of transcription from RNA polymerase II promoter during mitosis |
| RpS10a/CG12275 | E | E | Structural constituent of ribosome/neurogenesis |
| -/CG11985 | E | E | unknown/mitotic spindle organization |
| Prosbeta2/CG3329 | E | E | endopeptidase activity/catalytic constituent of the proteasome (beta-subunit), protein degradation |
| Rpn9/CG10230 | E | E | endopeptidase activity/regulation of exit from mitosis, protein degradation |
| bic/CG3644 | E | E | unknown/regulation of establishment of protein localization, RNA binding, intracellular mRNA localization |
| MRG15/CG6363 | S | S | unknown/chromatin silencing |
| Hop/CG2720 | S | S | unfolded protein binding/protein folding |
| -/CG6364 | E | E | Uridine kinase activity/phagocytosis, engulfment |
| -/CG6873 | E | E | Actin binding, polymerization/neurogenesis |
| Nrx-IV/CG6827 | E | E | transmembrane signaling receptor activity/dorsal closure; nerve maturation; regulation of tube size, open tracheal system; establishment of glial blood-brain barrier; septate junction assembly; axon ensheathment. |
| CycJ/CG10308 | E | E | cyclin-dependent protein kinase regulator activity/mitotic cell cycle, embryonic; mitosis |
| -/CG8086 | E | E | unknown/neurogenesis |
| bru/CG2478 | E | E | unknown/cytokinesesis |
| -/CG8108 | E | E | zinc ion binding/unknown |
| vnc/CG11989 | E | E | peptide alpha-N-acetyltransferase activity/oogenesis, neurogenesis |
| Smg5/CG8954 | E | E | unknown/nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Table lists gene name (if applicable) and gene ID of all candidates identified to have a similar effect on polyQ- and Tau-induced REPs. Mode of modification is indicated (enhancement (E), suppression (S)). A brief summary of the molecular and biological functions assigned to the identified gene products is listed.