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. Author manuscript; available in PMC: 2013 Nov 14.
Published in final edited form as: Neurosci Lett. 2012 Oct 13;530(1):59–63. doi: 10.1016/j.neulet.2012.09.060

Figure 2.

Figure 2

Effects of cocaine on POMC mRNA levels (pg/μg total RNA) in the medial hypothalamus of cocaine (0, 10 or 30 mg/kg) with conditioning (A) or without conditioning (B) in Sprague-Dawley rats in Experiment I and Experiment II. Data shown in graphs are treatment group mean + SEM. Significant differences are indicated: * p < 0.01 or ** p < 0.005. (C) In Experiment 2, regression of POMC mRNA levels in the medial hypothalamus and CPP expression during 30 min post-conditioning test in the rats (n=10) after 30 mg/kg cocaine conditioning. There was a significant positive correlation between the POMC mRNA level and CPP expression (difference in time spent in cocaine-paired and saline-paired compartments).