Table 2.
Loci identified using Metabochip to be associated with type 2 diabetes, fasting glucose, fasting insulin or 2-hour glucose
| Trait | SNP | Chr | Mb | Gene | Alleles | Freq | Odds ratio (CI)or Effect (SE) | P value |
|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes | rs12571751 | 10 | 80.6 | ZMIZ1 | A/G | .52 | 1.08 (1.05–1.10) | 1.0 × 10−10 |
| Type 2 diabetes | rs516946 | 8 | 41.6 | ANK1 | C/T | .76 | 1.09 (1.06–1.12) | 2.5 × 10−10 |
| Type 2 diabetes | rs10842994 | 12 | 27.9 | KLHDC5 | C/T | .80 | 1.10 (1.06–1.13) | 6.1 × 10−10 |
| Type 2 diabetes | rs2796441 | 9 | 83.5 | TLE1 | G/A | .57 | 1.07 (1.05–1.10) | 5.4 × 10−9 |
| Type 2 diabetes | rs459193 | 5 | 55.8 | ANKRD55 | G/A | .70 | 1.08 (1.05–1.11) | 6.0 × 10−9 |
| Type 2 diabetes | rs7202877 | 16 | 73.8 | BCAR1 | T/G | .89 | 1.12 (1.07–1.16) | 3.5 × 10−8 |
| Fasting glucose | rs16913693 | 9 | 110.7 | IKBKAP | T/G | .97 | .0434 (.007) | 3.5 × 10−11 |
| Fasting glucose | rs3829109 | 9 | 138.4 | DNLZ | G/A | .71 | .0172 (.003) | 1.1 × 10−10 |
| Fasting glucose | rs3783347 | 14 | 99.9 | WARS | G/T | .79 | .0168 (.003) | 1.3 × 10−10 |
| Fasting glucose | rs10747083 | 12 | 131.6 | P2RX2 | A/G | .66 | .0133 (.002) | 7.6 × 10−9 |
| Fasting glucose | rs6072275 | 20 | 39.2 | TOP1 | A/G | .16 | .0159 (.003) | 1.7 × 10−8 |
| Fasting glucose | rs576674 | 13 | 32.5 | KL | G/A | .15 | .0167 (.003) | 2.3 × 10−8 |
| Fasting glucose | rs11715915 | 3 | 49.4 | AMT | C/T | .68 | .0120 (.002) | 4.9 × 10−8 |
| Fasting glucose adjusted for BMI | rs17762454 | 6 | 7.2 | RREB1 | T/C | .26 | .0140 (.002) | 9.6 × 10−9 |
| Fasting glucose adjusted for BMI | rs2657879 | 12 | 55.2 | GLS2 | G/A | .18 | .0157 (.003) | 3.9 × 10−8 |
| Fasting insulin | rs9884482 | 4 | 106.3 | TET2 | C/T | .39 | .0165 (.002) | 1.4 × 10−11 |
| Fasting insulin | rs1167800 | 7 | 75.0 | HIP1 | A/G | .54 | .0156 (.003) | 2.6 × 10−9 |
| Fasting insulin | rs731839 | 19 | 38.6 | PEPD | G/A | .34 | .0145 (.003) | 1.7 × 10−8 |
| Fasting insulin | rs1530559 | 2 | 135.5 | YSK4 | A/G | .52 | .0145 (.003) | 3.4 × 10−8 |
| Fasting insulin adjusted for BMI | rs3822072 | 4 | 90.0 | FAM13A | A/G | .48 | .0116 (.002) | 1.8 × 10−8 |
| 2-hour glucose | rs1019503 | 5 | 96.3 | ERAP2 | A/G | .48 | .0628 (.011) | 8.9 × 10−9 |
The subset of loci shown have not previously been reported to be associated with another metabolic trait at genome-wide significance in Europeans [19, 21].
Chr, chromosome; Mb, megabase position; Gene, a nearby gene; Freq, frequency of the type 2 diabetes risk-increasing or quantitative trait-raising allele, listed first; CI, 95% confidence interval; SE, standard error.
Odds ratios are shown for type 2 diabetes loci. For quantitative traits, effects are shown in units of untransformed fasting glucose level, natural log-transformed fasting insulin level, or untransformed 2-hour glucose level.