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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: J Immunol. 2012 Oct 1;189(10):4921–4929. doi: 10.4049/jimmunol.1201916

Figure 3. Sendai virus infection induces susceptibility to secondary bacterial infection but the susceptibility wanes by day 26 after infection.

Figure 3

In Figure 2A–C, we demonstrated that exposure to Sendai virus, unlike exposure to H3N2 influenza, does not reduce the capacity of a subsequent (21 days later) H1N1 infection to induce susceptibility to S. pneumoniae (Spn) on day 5 after the H1N1 infection. To demonstrate that Sendai virus itself was not causing the observed susceptibility to Spn at 26 days after prior Sendai virus infection, C57BL/6 mice were infected with Sendai virus or treated with PBS vehicle and then challenged with Spn after 7 (A) or 26 days (B). Consistent with prior report (29), Sendai virus infection increased susceptibility to Spn significantly when mice were challenged on day 7 (p=0.001 by Log rank test; n=10 mice/group). However, this susceptibility was no longer evident when they were challenged on day 26.