Figure 11.
TEA increases the frequency of action potentials evoked by PSP clusters. A) Intracellular TEA increases the number of action potentials induced by spontaneous PSP clusters, consistent with increased summation of PSPS. B) This is readily observable when PSP clusters are overlayed in the presence of DNDS (left) compared to TEA (right). C) The frequency of action potential firing is significantly different over a range of membrane potentials. D) The half-width of action potentials was significantly longer when TEA was included in the pipette, consistent with an expected effect on voltage-gated K+ channels. * indicates p<0.05 in post-hoc Tukeys following significance in a two-way repeated measures ANOVA, or in t-test.