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. 2012 Aug 2;44(10):594–602. doi: 10.3858/emm.2012.44.10.068

Figure 2.

Figure 2

Increased ArgII activity was associated with eNOS uncoupling. (A) Increased eNOS expression in aged aorta was not attenuated by siArgII (* vs. young, P < 0.01; ** vs. aged, ns). (B) siArgII incubation induced eNOS coupling in young aorta (# vs. young, P < 0.01). Augmented eNOS uncoupling in aged aorta was decreased by siArgII. Incubation of aged aorta with the arginase inhibitor, ABH (10 µM), enhanced eNOS dimerization (* vs. young, P < 0.01; ** vs. aged, P < 0.01). Densitometric analysis of Western blot (lower panel).