Table 4. Association Between Haplotypes of SLC23A1 and SLC23A2 and Advanced Colorectal Adenomaa.
| Haplotype | SNPs | Exact P Value b |
|---|---|---|
| SLC23A1c | ||
| Block 1 | SLC23A1-18, -05, -09, and -21 | 0.92 |
| SLC23A2c | ||
| Region 1a | SLC23A2-31, -32, 08, -09, and -10 | 0.71 |
| Region 1b | SLC23A2-08, -09, and -10 | 0.67 |
| Region 2a | SLC23A2-33, -26, and -03 | 0.43 |
| Region 2b | SLC23A2-33 and -26 | 0.46 |
| Region 3 | SLC23A2-05 and -01 | 0.12 |
a
Abbreviations are as follows: SLC23A1, solute carrier family 23 (nucleobase transporters), member 1; SLC23A2, SLC23A member 2; SNP, single nucleotide polymorphism.
b
Global test for association between haplotypes and colorectal adenoma.
c
In SLC23A1, analysis by block structure as defined by Gabriel et al. (29). In SLC23A2, no haplotype blocks as defined by Gabriel et al. were identified. A sliding window of regions displaying high degree of linkage disequilibrium were utilized for exploratory analyses.