Table II.
Distribution of genotypes and alleles of thiopurine S-methyltransferase, 238G>C, 460G>A and 719A>G single nucleotide polymorphismsa, in a Southern Indian population, tested for Hardy-Weinberg equilibrium.
| Locus | Genotype counts (Frequency %) | Allele counts (Frequency %) | P-valueb | |||
|---|---|---|---|---|---|---|
| c.238G>C (rs1800462) | GG | GC | CC | G | C | |
|
|
|
|||||
| 324 (99.39) | 2 (0.61) | 0 | 650 (99.69) | 2 (0.31) | 0.96 | |
| c.460G>A (rs1800460) | GG | GA | AA | G | A | |
|
|
|
|||||
| 324 (99.39) | 2 (0.61) | 0 | 650 (99.69) | 2 (0.31) | 0.96 | |
| c.719A>G (rs1142345) | AA | AG | GG | A | G | |
|
|
|
|||||
| 321 (98.47) | 5 (1.53) | 0 | 647 (99.23) | 5 (0.77) | 0.89 | |
a
Ref. seq: NM_000367.2, based on cDNA.
b
P<0.05 is considered significant (Chi-square test for Hardy-Weinberg equilibrium).