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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Prostate. 2011 Dec 27;72(11):1214–1222. doi: 10.1002/pros.22472

Figure 1.

Figure 1

Histological comparison of wild-type and Ercc1−/− tissue recombinants treated with T&E2 at 8 weeks post-renal grafting. (A) Prostate tissue from host Nude mouse. (B) Wild-type tissue recombinants displayed normal glandular architecture and focal hyperplasia. Ercc1−/− tissue recombinants displayed (C) 2+ PIN-like lesions, and (D) focal areas of nuclear pleomorphism, abnormal mitosis and crowding with epithelial proliferation. Arrows point to cells in mitoses. (A–D, scale bar = 50 μm) (E) Tissue sections were stained with Hoechst 33258 stain, with the nucleus of mouse origin having a spotty appearance while the cells of rat origin have a diffuse appearance. (left, scale bar = 100 μm; right, scale bar = 33 μm)

HHS Vulnerability Disclosure