Table 1.

Histopathology of prostatic epithelial cells in wild-type and Ercc1^−/− tissue recombinants. The table depicts the most severe histopathological phenotype for each Ercc1^−/− and wild-type tissue recombinant at 8, 16 and 24 weeks post-renal grafting. Only Ercc1^−/− tissue recombinants displayed adenocarcinoma.

	Ercc1	(n)	Normal	Hyperplasia	PIN	Atypical glands with features of adenocarcinoma
8 week	+/+	11	2 (18%)	5 (46%)	4 (35%)	0 (0%)
	−/−	18	1 (5%)	3 (17%)	13 (72%)	1 (6%)*
16 week	+/+	15	1 (6%)	4 (27%)	10 (67%)	0 (0%)
	−/−	16	0 (0%)	0 (0%)	14 (87.5%)	2 (12.5%)#
24 week	+/+	13	4 (31%)	3 (23%)	6 (46%)	0 (0%)
	−/−	17	0 (0%)	0 (0%)	14 (82%)	3 (18%)+

Statistical significance between Ercc1^−/− and wild-type tissue recombinants were *p = 0.020, ^#p = 0.0065, and ⁺p = 0.0003 at the 8,16, and 24 week time points respectively. With serial grafting ERCC1−/− tissue recombinants progressed to a more severe histopathological phenotype more rapidly than wild-type (p=0.011).