Table 2.

Genes induced by spermidine in the arginine, citrulline and ornithine metabolism⁺

Gene names	Annoted functions	Fold increase
ARG1	Arginosuccinate synthetase, catalyzes formation of L-argininosuccinate from citrulline and L-aspartate	4.7
ARG2	Acetylglutamate synthase, first step in the biosynthesis of the arginine precursor ornithine	2
ARG3	Ornithine carbamoyltransferase, catalyzes the sixth step in ornithine biosynthesis	3
ARG4	Argininisuccinate lyase, this is the final step in arginine biosynthesis	4.6
ARG5.6	Processed in the mitochondrion to form acetylglutamate kinase and N-acetyl-gamma- glutamyl-phosphate reductase, catalyzes 2nd and 3rd steps in arginine biosynthesis	2.8
CPA2	Large subunit of carbamoyl phosphate synthetase, catalyzes the synthesis of citrulline, an arginine precursor	2.8
ECM40	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis	2.5
ORT1	Ornithine transporter to the mitochondria, exports ornithine from mitochondria for arginine biosynthesis	2