Table 3.

Genes induced by spermidine in the biotin, lysine and NAD (tryptophan) metabolism^⊥

Gene Names	Annoted functions	Fold induced
BIO5	Putative transmembrane protein, responsible for uptake of 7-keto 8-aminopelargonic acid	14.2
BIO3	Adenosylmethionine-8-amino-7-oxononanoate terminase, biotin biosynthesis	10.2
BIO4	Dithiobiotin synthase activity, biotin biosynthesis	9.9
BIO2	Biotin synthase activity, biotin biosynthesis	4.9
LYS9	Saccharopine dehydrogenase (L-glutamate forming), lysine biosynthesis, aminoadipic pathway	12
LYS1	Saccharopine dehydrogenase (L-lysine forming), lysine biosynthesis, aminoadipic pathway	10.1
LYS4	Homoaconitase, catalyzes the conversion of homocitrate homoisocitrate	4.4
LYS2	L-aminoadipate-semialdehyde dehydrogenase, lysine biosynthesis, aminoadipic pathway	3.7
LYS20	Homocitrate synthase, lysine biosynthesis, aminoadipic pathway	4.3
LYS12	Homo-isocitrate dehydrogenase, lysine biosynthesis	3
LYS21	Homocitrate synthase isozyme, catalyzes condensation of acetyl CoA and alpha-ketoglutarate to form homocitrate	3.4
BNA2	Tryptophan 2,3-dioxygenase, biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	11.1
BNA1	3-hydroxyanthranilic acid dioxygenase, biosynthesis of nicotinic acid from tryptophan via kynurenine pathway, NAD biosynthesis	3.4
BNA3	Arylformamidase, biosynthesis of nicotinic acid from tryptophan via kynurenine pathway, NAD biosynthesis;	3.7
BNA4	Kynurenine 3-mono oxygenase, biosynthesis of nicotinic acid from tryptophan via kynurenine pathway	3
BNA5	Kynureninase, required for de novo biosynthesis of NAD from tryptophan.	2.7