Table 6A.

Spermidine repressed genes involved in DNA, RNA binding and regulation of gene expression, splicing^±

Gene names	Annoted functions	Fold change
MBF1	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p, frameshift suppressor	−3.1
GIS1	JmjC domain-containing histone demethylase, transcription factor involved in the expression of genes during nutrient limitation	−2.1
HTL1	Component of the RSC chromatin remodeling complex, may function in chromosome stability, telomerase maintenance	−1.9
RAD51	Strand exchange protein, forms a helical filament with DNA that search for homology, involved in double-strand DNA break repair	−1.8
MIG2	Protein with zinc fingers, involved in repression of SUC2, multicopy inhibition of GAL gene expression	−1.8
RPA135	RNA polymerase I subunit A135, DNA directed RNA polymerase act	−1.6
ARP8	Nuclear actin-related protein involved in chromatin-remodeling enzyme complexes	−1.9
SNF11	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation	−1.7
RSA1	Protein involved in the assembly of 60S ribosomal subunits	−1.7
GAT2	Protein containing GATA family zinc-finger motifs, expression repressed by leucine	−1.9
SNT309	Component of NineTeen complex, involved in RNA splicing	−2
STP4	Protein containg a Kruppel-type zinc-finger domain	−2.4
MED7	Subunit of the RNA polymerase II mediator complex, essential for transcriptional regulation	−2.1
CIN5	Basic leucine zipper transcriptional factor of yAP-1 family, involed in drug resistance and salt tolerance	−2.4
TOF2	Topoisomerase I-interacting factor, may be involved in DNA topological changes	−1.8
SUT1	Transcription factor of the zinc family, involved in induction of hypoxic gene expression	−2
ECM2	Pre-mRNA splicing factor	−1.8
NPL3	RNA-binding protein, carries poly(A)+ mRNA from nucleus into the cytoplasm, phosphorylated by Sky1p	−1.8