Table 7.
Spermine controlled genes⇑ (*also changed by spermidine addition)
| Up-regulated genes | ||
|---|---|---|
| Gene symbol | Fold-change | Annoted Function |
| *CPA2 | 2.7 | Large subunit of carbamoyl phosphate synthetase, synthesis of citrulline, the arginine precursor |
| *ARG4 | 2.3 | Argininosuccinate lyase, arginine biosynthesis |
| YKL218C (SRY1) | 2.2 | 3-hydroxyaspartate dehydrogenase, serine racemase |
| RPL7B | 2.5 | Protein component of the 60S ribosomal subunit |
| *ECM40 | 2 | Mitochondrial ornithine acetyltransferase, ornithine biosynthesis |
| HIS5 | 1.7 | Histidinol-phosphate aminotransferase, histidine biosynthesis |
| *BNA1 | 2.2 | 3-hydroxyanthranilic acid dioxygenase, biosynthesis of nicotinic acid from tryptophan |
| *MEP3 | 2 | Ammonium permease, expresss under nitrogen catabolite repression |
| *MET13 | 1.6 | Isozyme of methylenetetrahydrofolate reductase, methionine biosynthesis |
| *LYS1 | 1.9 | Saccharopine dehydrogenase, lysine biosynthesis |
| SSU1 | 1.7 | Plasmamembrane sulfite pump, efficient sulfite efflux |
| MCH4 | 1.6 | Monocarboxylate transporter homolog, transport of monocarboxylic acid across the plasma membrane |
| YEL073C | 2 | Uncharacterized protein, regulated by inositol/choline |
| Down-regulated genes | ||
| Gene symbol | Fold-change | Annoted Function |
| HHO1 | −1.7 | Histone H1, suppresses DNA repair involving homologous recombination |
| PCL1 | −1.6 | Ph085 cyclin, involved in entry into the mitotic cell cycle |
| CLN2 | −1.7 | G1 cyclin involved in regulation of cell cycle, promotes G1to S phase transition |
| *SNF11 | −1.4 | Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation |
| BBP1 | −1.4 | Spindle pole body duplication, required for mitotic function of Cdc5p |
| SRL1 | −1.5 | Mannoprotein exhibiting tight association with cell wall, suppressor of Rad53p null lethality |
| CWC25 | −1.5 | Component of a pre-mRNA splicing complex containing Cef1p |