Table 1. Endogenous serum metabolites significantly affected by galN-treatment.
| Metabolite ID | m/z | RT | ID methoda | Salineb log(NS) | galNb log(NS) | log(FC)c | −log(p)d |
|---|---|---|---|---|---|---|---|
| AA Methionine | 150.06 | 0.87 | Standard | −3.3 | −2.8 | 0.58 | 3.21 |
| AA Proline | 116.07 | 0.61 | Standard | −0.7 | −0.2 | 0.56 | 2.75 |
| AA Threonine | 120.06 | 0.59 | Standard | −1.1 | −0.7 | 0.42 | 2.50 |
| AA Tyrosine | 182.08 | 0.98 | Standard | 0.0 | 1.0 | 1.00 | 4.25 |
| FFA Linoleic acid | 281.25 | 5.52 | Standard | −0.8 | −0.7 | 0.11 | 1.92 |
| Glucose | 383.12 | 0.59 | Standard | −0.1 | −0.3 | −0.16 | 2.74 |
| LysoPC(0:0/18:0) | 524.37 | 4.54 | MS/MS | 0.3 | −0.3 | −0.64 | 13.45 |
| LysoPC(14:0/0:0)) | 468.31 | 3.60 | Standard | −0.4 | −0.7 | −0.30 | 7.91 |
| LysoPC(15:0/0:0) | 482.32 | 3.83 | Standard | −0.3 | −0.7 | −0.33 | 7.31 |
| LysoPC(16:0/0:0)) | 496.34 | 4.09 | Standard | 1.7 | 1.3 | −0.42 | 11.14 |
| LysoPC(16:1/0:0) | 494.32 | 3.77 | MS/MS | 0.0 | −0.2 | −0.15 | 2.86 |
| LysoPC(17:0/0:0) | 510.36 | 4.37 | Standard | −0.1 | −0.6 | −0.47 | 7.14 |
| LysoPC(18:1/0:0) | 522.36 | 4.28 | Standard | 0.9 | 0.5 | −0.34 | 8.75 |
| LysoPC(18:3) | 518.32 | 3.98 | Database | −1.5 | −2.1 | −0.54 | 7.40 |
| LysoPC(19:0/0:0) | 538.38 | 4.96 | Standard | −0.5 | −1.0 | −0.51 | 6.39 |
| LysoPC(20:0/0:0) | 552.40 | 5.26 | Standard | −0.8 | −1.2 | −0.41 | 7.31 |
| LysoPC(20:1/0:0) | 550.39 | 4.81 | MS/MS | −0.2 | −1.0 | −0.75 | 10.16 |
| LysoPC(20:2/0:0) | 548.37 | 4.44 | MS/MS | −0.7 | −1.1 | −0.40 | 6.73 |
| LysoPC(20:3) | 546.36 | 4.54 | Database | −1.2 | −1.5 | −0.31 | 6.50 |
| LysoPC(20:4) | 544.34 | 3.99 | MS/MS | 1.2 | 1.0 | −0.22 | 4.34 |
| LysoPC(22:0) | 580.43 | 5.86 | Database | −1.1 | −1.3 | −0.23 | 6.83 |
| LysoPC(22:1/0:0) | 578.42 | 5.38 | MS/MS | −1.3 | −1.7 | −0.38 | 8.85 |
| LysoPC(22:5/0:0) | 570.36 | 4.12 | MS/MS | −1.1 | −0.9 | 0.21 | 2.71 |
| LysoPC(24:0) | 608.46 | 6.46 | Database | −0.9 | −1.0 | −0.09 | 1.71 |
| LysoPC(24:1/0:0) | 606.45 | 5.96 | MS/MS | −1.0 | −1.3 | −0.35 | 8.93 |
| LysoPC(O-16:0/0:0) | 482.36 | 4.21 | MS/MS | −0.6 | −1.1 | −0.57 | 12.59 |
| LysoPC(O-18:0/0:0) | 510.39 | 4.80 | MS/MS | −1.1 | −1.6 | −0.48 | 11.61 |
| LysoPC(O-20:0/0:0) | 538.42 | 5.41 | MS/MS | −1.5 | −1.8 | −0.37 | 9.32 |
| LysoPC(O-22:0/0:0) | 566.46 | 6.02 | MS/MS | −1.9 | −2.0 | −0.19 | 3.62 |
| LysoPC(P-18:0/0:0) | 508.37 | 4.39 | MS/MS | −0.7 | −1.4 | −0.69 | 13.95 |
| LysoPE(16:0) | 454.29 | 4.07 | MS/MS | −0.3 | 0.3 | 0.53 | 3.72 |
| LysoPE(18:0) | 482.32 | 4.64 | MS/MS | −0.1 | 0.2 | 0.37 | 3.44 |
| LysoPE(18:2) | 478.29 | 3.93 | MS/MS | −0.7 | 0.0 | 0.75 | 6.92 |
| LysoPE(20:4) | 502.29 | 3.97 | MS/MS | −0.6 | 0.2 | 0.74 | 4.52 |
| LysoPE(22:6) | 526.29 | 3.97 | Database | −1.2 | −0.4 | 0.83 | 4.15 |
| LysoPE(P-16:0/0:0) | 438.30 | 4.25 | MS/MS | −0.9 | −1.4 | −0.54 | 9.19 |
| PC(14:0/16:0) | 706.54 | 7.39 | Standard | −0.4 | −0.1 | 0.31 | 9.80 |
| PC(14:0/18:1) | 754.55 | 7.50 | MS/MS | −0.9 | −0.5 | 0.38 | 6.50 |
| PC(14:0/20:4) | 754.54 | 7.15 | MS/MS | −0.2 | 0.0 | 0.21 | 6.48 |
| PC(15:0/18:2) | 744.56 | 7.38 | MS/MS | 0.2 | 0.5 | 0.37 | 3.64 |
| PC(16:0/16:0) | 734.57 | 7.80 | MS/MS | 0.5 | 0.8 | 0.29 | 5.83 |
| PC(16:0/18:1) | 760.59 | 7.87 | Standard | 1.3 | 1.6 | 0.31 | 8.68 |
| PC(16:0/18:2) | 758.57 | 7.58 | Standard | 1.9 | 2.1 | 0.20 | 9.44 |
| PC(16:0/20:5) | 780.56 | 7.25 | MS/MS | 0.3 | 0.5 | 0.20 | 4.58 |
| PC(17:0/18:2) | 772.59 | 7.77 | MS/MS | 0.3 | 0.7 | 0.44 | 4.76 |
| PC(18:0/18:2) | 786.61 | 7.97 | Standard | 1.5 | 1.8 | 0.24 | 10.96 |
| PC(18:0/20:4) | 810.60 | 7.92 | Standard | 2.0 | 1.8 | −0.15 | 7.61 |
| PC(18:0/22:6) | 834.60 | 7.68 | Standard | −0.3 | −0.9 | −0.60 | 1.85 |
| PC(18:1/20:4) | 808.59 | 7.63 | MS/MS | 1.4 | 1.2 | −0.20 | 4.83 |
| PC(18:2/18:2) | 782.57 | 7.56 | Standard | 2.0 | 2.0 | −0.03 | 3.02 |
| PC(P-16:0/20:4) | 766.58 | 7.71 | MS/MS | 0.3 | 0.1 | −0.20 | 7.64 |
| PC(P-18:0/20:4) | 794.61 | 7.79 | MS/MS | 0.4 | 0.2 | −0.25 | 8.72 |
| PC(P-18:1/20:2) | 796.62 | 7.98 | Database | −0.6 | −1.0 | −0.41 | 5.72 |
| PE(16:0/18:2) | 716.52 | 7.61 | MS/MS | −0.8 | 0.3 | 1.14 | 3.51 |
| SM (d18:1/16:0) | 703.58 | 6.99 | MS/MS | 1.2 | 0.9 | −0.26 | 9.07 |
| SM (d18:1/18:0) | 731.61 | 7.49 | MS/MS | 0.2 | 0.0 | −0.15 | 3.35 |
| SM(d18:1/14:0) | 675.54 | 6.50 | MS/MS | −0.8 | −1.0 | −0.20 | 5.88 |
| SM(d18:1/15:0) | 689.56 | 6.75 | MS/MS | −0.5 | −0.8 | −0.28 | 7.11 |
a
Metabolite identification method is indicated
b
Log of the normalized signal (NS)
c
Log of the average fold change (FC) between galN vs saline-treated rats (negative value = down regulation, positive value = up regulation)
d
−log(p) value of Welch's t-test between galN and saline-treated rats