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. 2012 Aug 21;21(23):5039–5047. doi: 10.1093/hmg/dds348

Figure 1.

Figure 1.

Fragile X premutation RNA impairs female fertility. (A) immunohistochemistry staining of Fmrp in the ovary of a 9-week-old WT mouse. Brown staining indicates immunoreactivity and nuclei are counterstained blue. Bar: 50 µm. GC, granulosa cell; Oo, oocyte; TC, theca cell; AnF, antral follicle; PrF, primary follicle. (B) Lifespan breeding assays started at ∼8 weeks of age. Comparison of the cumulative number of pups per fragile X premutation (TG296-Premutation) female (blue line) and per WT littermate (green line), n = 7 for WT mice, n = 8 for TG296 mice. (C) the ages of mothers at first delivery (mean ± SD). (D) the litter sizes of WT and premutation females (mean ± SD). N = 13 for premutation mice, n = 9 for WT mice. (E) the body weights of females at different ages (mean ± SD). (F) Graph of the uterus/body weight ratio of females at 9 weeks of age (mean ± SD). Statistical significance (∗P < 0.05) was calculated by Student's t-test.