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. 2012 Aug 24;21(23):5091–5105. doi: 10.1093/hmg/dds355

Figure 2.

Figure 2.

Bezafibrate treatment affected GSK3β phosphorylation in P301S mice. (A) Western blots of phospho-GSK3β and total GSK3β, and (B and C) quantification by optical densities in wild-type mice fed a control diet (Wt Cont, n = 5), wild-type fed a bezafibrate (Wt Beza, n = 2), P301S mice fed a control diet (Tg Cont, n = 5) and P301S mice fed a bezafibrate diet (Tg Beza, n = 5). (C) Levels of total GSK3β mRNA in wild-type mice fed a control diet (Wt Cont, n = 7), wild-type fed a bezafibrate (Wt Beza, n = 6), P301S mice fed a control diet (Tg Cont, n = 7) and P301S mice fed a bezafibrate diet (Tg Beza, n = 7). Bezafibrate treatment affected the phosphorylation of GSK3β levels in P301S mice, without affecting total GSK3β mRNA and protein levels (Fisher's PLSD, *P < 0.05).