Figure 10.

H₂O₂ in cortical mitochondria isolated from 6-, 12- and 24-month-old APP mice and age-matched non-transgenic WT mice. Significantly increased production of H₂O₂ was found in the cerebral cortex from the 6-month-old (P = 0.01), 12-month-old (P = 0.002) and 24-month-old (P = 0.002) APP mice, compared with the 6-, 12- and 24-month-old non-transgenic WT mice. Significantly increased H₂O₂ was found in the 12-month-old (P = 0.04) and 24-month-old (P = 0.01) APP mice, compared with 6-month-old APP mice.