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. 2012 Aug 27;21(23):5131–5146. doi: 10.1093/hmg/dds360

Figure 14.

Figure 14.

Fission-linked GTPase activity in cortical tissues from 6-, 12- and 24-month-old APP mice and age-matched non-transgenic WT mice. Significantly increased GTPase activity was found in the cerebral cortical tissues from the 12-month-old (P = 0.002) and 24-month-old (P = 0.001) APP mice, compared with the 12- and 24-month-old non-transgenic WT mice. Significantly increased GTPase activity was found in the 12-month-old (P = 0.02) and 24-month-old (P = 0.01) APP mice, compared with the 6-month-old APP mice.