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Notch inhibition with DAPT (5 μM) reduces corneal epithelial cell attachment to fibronectin-collagen coated plates by 34.5% compared with DMSO (control). (P < 0.001) (A). In contrast, Jagged1 treated cells were 18% more adherent to the matrix compared with control (P < 0.01) (B). HCE-T transduced with Notch1 (N1) shRNA likewise demonstrated 29% lower matrix attachment compared with NS shRNA transduced HCE-T cells (P < 0.001) (C). Asterisk represents statistically significant data.
