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Proposed biosynthesis of hyperxanthone E in H. calycinum cell cultures. Cinnamic acid is the precursor of both C6-C1 benzenoids and C6-C3 phenylpropanoids. BPS, Benzophenone synthase; C4H, cinnamate 4-hydroxylase; CoASH, coenzyme A; DMAPP, dimethylallyl pyrophosphate.