Mapping of evolutionary contrasted amino acid sites on the three-dimensional model of a typical STS protein. VvSTS10 protein was modeled using the structure of STS from Scots pine as a template (Austin et al., 2004). In both STS monomers, remarkable amino acids are highlighted in red or blue, for amino acids subjected to positive or purifying selection, respectively. Pro-269, subjected to early positive selection in the grapevine STS family, is represented in purple. The position of the resveratrol product (R) is indicated.