Table 1.

Preparation of Epidithiodiketopiperazines^a

Entry	Substrate	Productb	Overall Yield [%]c
1	29	30	40
2	31	32	63
3	33	34	70
4	24	27	69
5	35	36	65
6	37	38	45
7	39	40	43
8	41	42	65
9	43	44	68
10	45	46	55d
11	47	48	68
12	49	50	70

^aReactions were performed on 100 mg scale at 25 °C.

^bRacemic mixture unless otherwise stated.

^cYield of isolated products after chromatography.

^dca. 1.4:1 dr.