Table 1.
Characteristics of Study 1: Autopsy Study
| Characteristic | Autopsy-Confirmed Cerebral Malaria Cause of Death n = 47 | Nonmalarial Cause of Death n = 17 | P Value |
|---|---|---|---|
| Gender, % male | 48.9 | 70.6 | .16 |
| Age in months | 49.0 ± 37.1 | 35.0 ± 17.9 | .17 |
| Admission laboratory values | |||
| Parasitemia, parasites/μLa | 45 486 | 12 407 | .08 |
| Hematocrit, % | 21.4 ± 7.3 | 31.4 ± 9.1 | <.001 |
| Lactate, mmol/L | 10.1 ± 4.4 | 5.1 ± 2.9 | <.01 |
| pHRP2 concentration, ng/mL | 12 800 ± 7057 | 1028 ± 2970 | <.001 |
| Platelets, per μL | 77 710 ± 64 821 | 181 533 ± 109 501 | <.001 |
| White blood cell count, per μL | 16 120 ± 13 158 | 17 787 ± 11 304 | .67 |
| HIV positive, % | 32.6 | 6.3 | .05 |
| Time to death in hours | 19.4 ± 20.8 | 29.4 ± 36.5 | .18 |
Abbreviations: HIV, human immunodeficiency virus; pHRP2, parasite histidine-rich protein 2.
aGeometric mean.