Table 3.
Characteristics of Study 3: Prospective Validation Group
| Characteristic | Retinopathy Positive (n = 71) | Retinopathy Negative (n = 30) | P Value |
|---|---|---|---|
| Gender, % male | 47.8 | 50 | 1.00 |
| Age in months | 45.3 ± 25.3 | 51.7 ± 25.3 | .25 |
| Temperature on admission, °C | 38.8 ± 1.3 | 39.0 ± 1.1 | .40 |
| Blantyre Coma Score on admission | 1.3 ± 0.6 | 1.3 ± 0.6 | .78 |
| History of convulsions, % positive | 85.7 | 93.5 | .33 |
| History of hypoglycemia,a % positive | 36.6 | 33.3 | .66 |
| Laboratory values on admission | |||
| Parasitemia, per μLb | 60 621 | 28 280 | .20 |
| Hematocrit | 19.5 ± 5.3 | 29.3 ± 6.5 | <.001 |
| Lactate, mmol/L | 7.7 ± 4.9 | 6.0 ± 3.7 | .09 |
| pHRP-2, ng/μL | 6668 ± 5041 | 810 ± 916 | <.001 |
| Platelets, per μL | 71 809 ± 61 558 | 171 923 ± 107 125 | <.001 |
| WBCs, per μL | 13 415 ± 10 519 | 13 712 ± 9 481 | .90 |
| HIV positive, % | 7.5 | 16.7 | .24 |
| Fever clearance time in hours | 44.2 ± 49.7 | 44.8 ± 37.1 | .96 |
| Coma resolution time in hours | 49.5 ± 37.7 | 32.1 ± 22.7 | .04 |
| Parasite clearance time in hours | 42.8 ± 14.2 | 37.9 ± 14.3 | .13 |
| Mortality rate, % | 14.3 | 19.4 | .56 |
Abbreviations: HIV, human immunodeficiency virus; pHRP2, parasite histidine-rich protein 2; WBCs, white blood cells.
a Whole blood glucose concentration ≤2.2 mmoL/L.
b Geometric mean.