Table 2.
Relationship between MMP-2, MMP-9 and type IV collagen expression and clinic-pathological parameters in 48 patients with tongue carcinoma
| Variable |
MMP-2 |
MMP-9 |
Type IV collagen |
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Stromal cells |
P |
Tumour cells |
P |
Stromal cells |
P |
Tumour cells |
P |
Low |
High |
P | ||||||
| Low | High | Low | High | Low | High | Low | High | |||||||||
| Gender |
Male |
14 |
22 |
1.000 |
31 |
5 |
1.000 |
6 |
30 |
0.672 |
11 |
25 |
1.000 |
24 |
12 |
0.139 |
| Female |
5 |
7 |
11 |
1 |
3 |
9 |
4 |
8 |
11 |
1 |
||||||
| Age |
<55 |
9 |
12 |
0.683 |
18 |
3 |
1.000 |
5 |
16 |
0.477 |
5 |
16 |
0.327 |
17 |
4 |
0.269 |
| ≥55 |
10 |
17 |
24 |
3 |
4 |
23 |
10 |
17 |
18 |
9 |
||||||
| Differentiation |
Advanced |
11 |
13 |
0.2 |
24 |
0 |
0.022▲ |
7 |
17 |
0.137 |
8 |
16 |
0.756 |
15 |
9 |
0.104 |
| Medium/poor |
8 |
16 |
18 |
6 |
2 |
22 |
7 |
17 |
20 |
4 |
||||||
| Clinical stage |
I+II |
12 |
15 |
0.435 |
21 |
6 |
0.029▲ |
8 |
19 |
0.058 |
9 |
18 |
0.724 |
18 |
9 |
0.269 |
| III+IV |
7 |
14 |
21 |
0 |
1 |
20 |
6 |
15 |
17 |
4 |
||||||
| T stage |
T1+T2 |
19 |
26 |
0.267 |
40 |
5 |
0.336 |
9 |
36 |
1.000 |
15 |
30 |
0.542 |
32 |
13 |
0.553 |
| T3+T4 |
0 |
3 |
2 |
1 |
0 |
3 |
0 |
3 |
3 |
0 |
||||||
| Recurrence |
No |
15 |
18 |
0.217 |
28 |
5 |
0.650 |
6 |
27 |
1.000 |
12 |
21 |
0.328 |
22 |
11 |
0.182 |
| Yes |
4 |
11 |
14 |
1 |
3 |
12 |
3 |
12 |
13 |
2 |
||||||
| Lymph node involvement | No |
10 |
1 |
<0.001★ | 11 |
0 |
0.313 | 6 |
5 |
0.002★ | 8 |
3 |
0.002★ | 5 |
6 |
0.048▲ |
| Yes | 9 | 28 | 31 | 6 | 3 | 34 | 7 | 30 | 30 | 7 | ||||||
▲Correlation was significant at the 0.05 level (two-tailed).
★Correlation was significant at the 0.01 level (two-tailed).