Figure 2.

CD103 or CD34 are not required for murine peanut-induced anaphylaxis. Mice were sensitized with peanut antigen and cholera toxin via oral gavage for 4 consecutive weeks and were challenged i.p. with crude peanut extract 2 weeks following the final sensitization. Body temperature decreases (A) and average clinical scores (B) monitored every 10 minutes; observed for 40 minutes post-injection. Following the 40-minute endpoint, blood levels of histamine were assayed (C). (Cd34^−/− n = 10, Cd103^−/− n = 4, Bl/6 n = 10, representative of 2–3 experiments. *represents p < 0.05; **represents p < 0.01; Error bars = SEM).