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. 2012 Nov 6;7(11):e48590. doi: 10.1371/journal.pone.0048590

Figure 1. MitoQ (100 µM) blunts tubular injury following cold storage.

Figure 1

(A) Representative 400X micrographs of PAS staining in renal cortical section of pig after 24 and 48 h of cold storage (CS) and CS + MitoQ. Representative bar indicates 50 µm. Thin arrows indicate loss of brush border; thick arrows indicate renal epithelial cell detachment and/or cell sloughing; arrow heads indicate epithelial cell degeneration; and asterisks indicate tubular casts. (B) Pathological scoring for tubular injury as a result of cold storage. Error bar indicates Mean ± S.E.M. (n = 5 for both groups). Cold storage significantly induced renal tubular damage at 48 h time point (P = 0.03), and MitoQ significantly blunted this injury (P = 0.01).