Table 4.
Allelic distributions and related OR values
| FPN1-8CG | HFEH63D | HFEC282Y | HEPC-582AG | TFP570S | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Allele (%) |
C |
G |
H |
D |
C |
Y |
A |
G |
P |
S |
|
|
All subjects (n=828) |
629 (76.0) |
199 (24.0) |
689 (83.2) |
139 (16.8) |
802 (96.86) |
26 (3.14) |
585 (70.6) |
243 (29.3) |
678 (81.9) |
150 (18.1) |
|
|
OR (95%CI) |
1.52 (1.2-1.93) |
1.23 (0.94-1.6) |
0.76 (0.45-1.27) |
1.30 (1.05-1.62) |
1.04 (0.81-1.34) |
||||||
|
P uncorrected |
<0.0001 |
NS |
NS |
0.020 |
NS |
||||||
|
(P corrected) |
(<0.002) |
(NS) |
(NS) |
(NS) |
(NS) |
||||||
|
RR (n=546) |
416 (76.2) |
130 (23.8) |
457 (83.7) |
89 (16.3) |
532 (97.4) |
14 (2.6) |
402 (73.6) |
144 (26.4) |
453 (83.0) |
93 (17.0) |
|
|
OR (95%CI) |
1.5 (1.15-1.95) |
1.18 (0.88-1.6) |
0.61 (0.33-1.16) |
1.12 (0.88-1.44) |
0.97 (0.73-1.29) |
||||||
|
P uncorrected |
0.004 |
NS |
NS |
NS |
NS |
||||||
|
(P corrected) |
(NS) |
(NS) |
(NS) |
(NS) |
(NS) |
||||||
|
PP + SP (n=282) |
213(75.5) |
69 (24.5) |
232 (82.3) |
50 (17.7) |
270 (96.86) |
12 (3.14) |
183 (64.9) |
99 (35.1) |
225 (79.8) |
57 (20.2) |
|
|
OR (95%CI) |
1.55 (1.12-2.15) |
1.31 (0.91-1.88) |
1.04 (0.53-2.03) |
1.7 (1.27-2.27) |
1.19 (0.85-1.68) |
||||||
|
P uncorrected |
0.010 |
NS |
NS |
<0.0001 |
NS |
||||||
|
(P corrected) |
(NS) |
(NS) |
(NS) |
(<0.002) |
(NS) |
||||||
|
OR1(95%CI) |
1.03 (0.74-1.45) |
1.10 (0.75-1.61) |
1.7 (0.8-3.7) |
1.51 (1.11-2.06) |
1.23 (0.86-1.78) |
||||||
|
P uncorrected |
NS |
NS |
NS |
0.010 |
NS |
||||||
|
(P corrected) |
(NS) |
(NS) |
(NS) |
(NS) |
(NS) |
||||||
| Controls (n=828) | 685 (82.7) | 143 (17.3) | 711 (85.9) | 117 (14.1) | 794 (95.9) | 34 (4.1) | 628 (75.9) | 200 (24.1) | 683 (82.5) | 145 (17.5) | |
All OR calculations are obtained computing the rare vs the common allele comparing cases vs controls. OR1 is referred to the Progressive group in which the reference category is the RR subgroup. Corrected and uncorrected P-values are respectively referred to the presence/absence of Bonferroni correction. NS, not significant.