Figure 2. Solution structure of AcCYS.

(A) The ensemble of 20 best structures of the inhibitory domain of AcCYS (res 41 to 135) is superimposed. The α-helical, β-sheet, and loop region is color coded in red, green, and grey respectively. (B) Ribbon representation of the inhibitory domain of AcCYS structure shows a αβ roll structure made up of one α-helix and four anti-parallel β-strands, β₁–β₄. Three regions which contain the highly conserved motifs are labeled as CM1–3. Side chains of these highly conserved residues including, G45, Q⁸⁹VVSG, and W120 are shown in spheres. These diagrams were generated using the structural visualization program PYMOL.