Table 1.
Quality and characteristics of included studies
| Reference | Date | Design | Jadad score | Treatment | Number of patients | Sex (M/F) | Mean age (years) | Tumor number (single/multiple) | Mean tumor size (cm) |
|---|---|---|---|---|---|---|---|---|---|
| Nishikawa |
2011 |
NRCT |
1 |
SR |
69 |
50/19 |
67.4 ± 9.7 |
69/0 |
2.68 ± 0.49 |
| |
|
|
|
RFA |
162 |
95/67 |
68.4 ± 8.7 |
162/0 |
1.99 ± 0.62 |
| Tashiro |
2011 |
NRCT |
1 |
SR |
199 |
137/62 |
65.7 ± 9.0 |
132/67 |
2.1 ± 0.63 |
| |
|
|
|
RFA |
87 |
53/34 |
66.3 ± 8.2 |
67/20 |
1.8 ± 0.52 |
| HUNG |
2011 |
NRCT |
1 |
SR |
229 |
184/45 |
60.07 ± 12.56 |
181/48 |
2.88 ± 1.06 |
| |
|
|
|
RFA |
190 |
121/69 |
67.42 ± 11.45 |
152/38 |
2.37 ± 0.92 |
| Nanashima |
2010 |
NRCT |
1 |
SR |
144 |
112/32 |
63.6 ± 8.8 |
128/16 |
NA |
| |
|
|
|
RFA |
56 |
36/20 |
67.7 ± 8.5 |
51/5 |
NA |
| Huang |
2010 |
RCT |
4 |
SR |
115 |
85/30 |
55.91 ± 12.68 |
89/26 |
NA |
| |
|
|
|
RFA |
115 |
79/36 |
56.57 ± 14.30 |
84/31 |
NA |
| Ueno |
2009 |
NRCT |
1 |
SR |
123 |
82/41 |
67 (28 to 85) |
110/13 |
2.7 ± 0.1 |
| |
|
|
|
RFA |
155 |
100/55 |
66 (40 to 79) |
101/54 |
2.0 ± 0.1 |
| Guglielmi |
2008 |
NRCT |
1 |
SR |
91 |
73/18 |
NA |
69/22 |
NA |
| |
|
|
|
RFA |
109 |
88/21 |
NA |
65/44 |
NA |
| Hiraoka |
2008 |
NRCT |
1 |
SR |
59 |
44/15 |
62.4 ± 10.6 |
NA |
22.7 ± 5.5 |
| |
|
|
|
RFA |
105 |
76/29 |
69.4 ± 9.1 |
NA |
19.8 ± 5.2 |
| Abu-Hilal |
2008 |
NRCT |
3 |
SR |
34 |
26/8 |
67 |
NA |
3.8 (1.3 to 5) |
| |
|
|
|
RFA |
34 |
27/7 |
65 |
NA |
3 (2 to 5) |
| Takahashi |
2007 |
NRCT |
1 |
SR |
53 |
39/14 |
66 (41 to 80) |
41/12 |
2.5 (1 to 5) |
| |
|
|
|
RFA |
171 |
120/51 |
69 (44 to 84) |
124/47 |
2.1 (0.7 to 4.8) |
| Chen |
2006 |
RCT |
4 |
SR |
90 |
75/15 |
49.4 ± 10.9 |
NA |
NA |
| |
|
|
|
RFA |
71 |
56/15 |
51.9 ± 11.2 |
NA |
NA |
| Hong |
2005 |
NRCT |
1 |
SR |
93 |
69/24 |
49.2 ± 9.9 |
NA |
2.5 ± 0.8 |
| |
|
|
|
RFA |
55 |
41/14 |
59.1 ± 9.6 |
NA |
2.4 ± 0.6 |
| Vivarell |
2004 |
NRCT |
2 |
SR |
79 |
57/22 |
65.2 ± 8.2 |
66/13 |
NA |
| RFA | 79 | 67/12 | 67.8 ± 8.7 | 46/33 | NA |
NA: Not available; NRCT: non-randomized controlled trial; RCT: randomized controlled trial; RFA: radiofrequency ablation; SR: surgical resection.