The bars indicate the number of years of life lost for each category, and the vertical lines are the 95% CIs. The reference category is normal weight and 7.5+ MET-h/wk of physical activity (i.e., meeting US recommended physical activity levels). Normal weight is a BMI of 18.5–24.9 kg/m2, overweight is a BMI of 25.0–29.9 kg/m2, obese class I is a BMI of 30.0–34.9 kg/m2, and obese class II+ is a BMI of 35.0 kg/m2 or greater. Years of life expectancy lost after age 40 were derived using direct adjusted survival curves [31],[32] for participants who were 40+ y of age at baseline and not underweight (96.5% of participants). Life expectancy models used age as the underlying time scale and were adjusted for gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9, 30.0+ g/d), education (did not complete high school, completed high school, post-high-school training, some college, completed college), marital status (married, divorced, widowed, unmarried), history of heart disease, history of cancer, and smoking status (never, former, current).