Table 4. Leisure time physical activity and multivariable hazard ratio of mortality, stratified by cohort.
| Study | Number of Deaths | Physical Activity Level (MET-h/wk) | |||||
| 0 | 0.1–3.74 | 3.75–7.4 | 7.5–14.9 | 15.0–22.4 | 22.5+ | ||
| AARP | 36,782 | 1.0 (ref) | 0.80 (0.76, 0.84) | 0.68 (0.65, 0.72) | 0.59 (0.57, 0.62) | 0.52 (0.50, 0.55) | 0.48 (0.45, 0.50) |
| CLUE II | 2,049 | 1.0 (ref) | 0.73 (0.63, 0.84) | 0.62 (0.54, 0.71) | 0.57 (0.50, 0.65) | 0.61 (0.50, 0.74) | 0.52 (0.42, 0.64) |
| CPS II | 38,776 | 1.0 (ref) | 0.80 (0.77, 0.83) | 0.79 (0.74, 0.83) | 0.70 (0.68, 0.72) | 0.65 (0.62, 0.68) | 0.65 (0.63, 0.67) |
| USRT | 2,450 | 1.0 (ref) | 0.71 (0.63, 0.80) | 0.54 (0.45, 0.66) | 0.57 (0.51, 0.64) | 0.54 (0.46, 0.63) | 0.55 (0.49, 0.62) |
| WHS | 2,167 | 1.0 (ref) | 0.87 (0.76, 0.99) | 0.79 (0.67, 0.92) | 0.70 (0.60, 0.81) | 0.80 (0.68, 0.94) | 0.82 (0.70, 0.94) |
| WLH | 241 | 1.0 (ref) | 0.44 (0.29, 0.68) | 0.36 (0.23, 0.58) | 0.30 (0.19, 0.45) | 0.35 (0.22, 0.56) | 0.40 (0.27, 0.59) |
| Pooled | 82,465 | 1.0 (ref) | 0.81 (0.79, 0.83) | 0.76 (0.74, 0.78) | 0.68 (0.66, 0.69) | 0.61 (0.59, 0.63) | 0.59 (0.57, 0.61) |
| Meta-analysisa | 82,465 | 1.0 (ref) | 0.78 (0.73, 0.83) | 0.66 (0.59, 0.75) | 0.60 (0.53, 0.67) | 0.59 (0.51, 0.68) | 0.57 (0.48, 0.68) |
| I 2 (p-value) | — | — | 64.6% (0.02) | 86.7% (<0.01) | 92.6% (<0.01) | 92.1% (<0.01) | 95.8% (<0.01) |
HRs (95% CIs) were calculated in models that used age as the underlying time scale. Multivariable models were adjusted for gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9, 30.0+ g/d), education (did not complete high school, completed high school, post-high-school training, some college, completed college), marital status (married, divorced, widowed, unmarried), history of heart disease, history of cancer, BMI (<18.5, 18.5–19.9, 20–22.4, 22.5–24.9, 25–27.4, 27.5–29.9, 30+ kg/m2), and smoking status (never, former, current).
Meta-analysis estimates were calculated using DerSimonian and Laird random effects models [29], and statistical heterogeneity was assessed by the I 2 statistic [30].
AARP, NIH-AARP Diet and Health Study; ref, reference; USRT, U.S. Radiologic Technologists cohort; WHS, Women's Health Study; WLH, Women's Lifestyle and Health study.